ImageCLEF 2013: The vision, the data and the open challenges

This paper presents an overview of the ImageCLEF 2013 lab. Since its first edition in 2003, ImageCLEF has become one of the key initiatives promoting the benchmark evaluation of algorithms for the cross-language annotation and retrieval of images in various domains, such as public and personal images, to data acquired by mobile robot platforms and botanic collections. Over the years, by providing new data collections and challenging tasks to the community of interest, the ImageCLEF lab has achieved an unique position in the multi lingual image annotation and retrieval research landscape. The 2013 edition consisted of three tasks: the photo annotation and retrieval task, the plant identification task and the robot vision task. Furthermore, the medical annotation task, that traditionally has been under the ImageCLEF umbrella and that this year celebrates its tenth anniversary, has been organized in conjunction with AMIA for the first time. The paper describes the tasks and the 2013 competition, giving an unifying perspective of the present activities of the lab while discussion the future challenges and opportunities.This work has been partially supported by the Halser Foundation (B. C.),by the LiMoSINe FP7 project under grant # 288024 (B. T.), by the Khresmoi (grant# 257528) and PROMISE ( grant # 258191) FP 7 projects (H.M.) and by the tranScriptorium FP7 project under grant # 600707 (M. V., R. P.)Caputo ., B.; Muller ., H.; Thomee ., B.; Villegas, M.; Paredes Palacios, R.; Zellhofer ., D.; Goeau ., H.... (2013). ImageCLEF 2013: The vision, the data and the open challenges. En Information Access Evaluation. Multilinguality, Multimodality, and Visualization. Springer Verlag (Germany). 8138:250-268. https://doi.org/10.1007/978-3-642-40802-1_26S2502688138Muller, H., Clough, P., Deselaers, T., Caputo, B.: ImageCLEF: experimental evaluation in visual information retrieval. 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In: Peters, C., Clough, P., Gonzalo, J., Jones, G.J.F., Kluck, M., Magnini, B. (eds.) CLEF 2004. LNCS, vol. 3491, pp. 597–613. Springer, Heidelberg (2005)Clough, P., Müller, H., Deselaers, T., Grubinger, M., Lehmann, T.M., Jensen, J., Hersh, W.: The CLEF 2005 cross–language image retrieval track. In: Peters, C., Gey, F.C., Gonzalo, J., Müller, H., Jones, G.J.F., Kluck, M., Magnini, B., de Rijke, M., Giampiccolo, D. (eds.) CLEF 2005. LNCS, vol. 4022, pp. 535–557. Springer, Heidelberg (2006)Müller, H., Deselaers, T., Deserno, T., Clough, P., Kim, E., Hersh, W.: Overview of the imageCLEFmed 2006 medical retrieval and medical annotation tasks. In: Peters, C., Clough, P., Gey, F.C., Karlgren, J., Magnini, B., Oard, D.W., de Rijke, M., Stempfhuber, M. (eds.) CLEF 2006. LNCS, vol. 4730, pp. 595–608. Springer, Heidelberg (2007)Müller, H., Deselaers, T., Deserno, T., Kalpathy–Cramer, J., Kim, E., Hersh, W.: Overview of the imageCLEFmed 2007 medical retrieval and medical annotation tasks. 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The role of bacterial colonization of the suture thread in early identification and targeted antibiotic treatment of surgical site infections: A prospective cohort study

Background: The aim of the present study is to investigate the role of the colonization of suture thread to identify patients at risk of developing a surgical site infection (SSI) after clean surgical procedures. Methods: Patients who underwent elective clean surgery procedures at the Surgery Unit of the AOU-University of Campania Luigi Vanvitelli in a 21-month period were prospectively enrolled. For each patient, a synthetic absorbable thread in Lactomer 9-1 was inserted into the surgical site at the end of surgery and microbiologically evaluated after 48 h. Antibiotic prophylaxis was chosen according to international guidelines. Results: A total of 238 patients were enrolled; 208 (87.4%) of them were subjected to clean procedures without the placement of prosthesis, and 30 (12.6%) with prosthesis. Of the 238 patients, 117 (49.2%) underwent an antimicrobial prophylaxis. Overall, 79 (33.2%) patients showed a bacterial colonization of the thread: among the 208 without the implantation of prosthesis, 19 (21.8%) of the 87 with antibiotic prophylaxis and in 58 (47.9%) of the 121 without it; among the 30 patients with the implantation of prosthesis, only two patients showed a colonized thread. The patients with antibiotic prophylaxis developed a colonization of the thread less frequently than those without it (17.9% vs. 47.9%, p < 0.001). SSI was observed in six (2.5%) patients, all of them showing a colonized thread (7.6% vs. 0%, p < 0.001). The bacteria identified in colonized threads were the same as those found in SSIs. Conclusions: Our study presents a new method that is able to precociously assess patients who have undergone clean procedures who may develop SSI, and identify the microorganism involved

Three-dimensional superimposition for patients with facial palsy: an innovative method for assessing the success of facial reanimation procedures

Facial palsy is a severe condition that may be ameliorated by facial reanimation, but there is no consensus about how to judge its success. In this study we aimed to test a new method for assessing facial movements based on 3-dimensional analysis of the facial surfaces. Eleven patients aged between 42 and 77 years who had recently been affected by facial palsy (onset between 6 and 18 months) were treated by an operation based on triple innervation: the masseteric to temporofacial nerve branch, 30% of the hypoglossal fibres to the cervicofacial nerve branch, and the contralateral facial nerve through two cross-face sural nerve grafts. Each patient had five stereophotogrammetric scans: at rest, smiling on the healthy side (facial stimulus), biting (masseteric stimulus), moving the tongue (hypoglossal stimulus), and corner-of-the-mouth smile (Mona Lisa). Each scan was superimposed onto the facial model of the "rest" position, and the point-to-point root mean square (RMS) value was automatically calculated on both the paralysed and the healthy side, together with an index of asymmetry. One-way and two-way ANOVA tests, respectively, were applied to verify the significance of possible differences in the RMS and asymmetry index according to the type of stimulus (p = 0.0329) and side (p < 0.0001). RMS differed significantly according to side between the facial stimulus and the masseteric one on the paralysed side (p = 0.0316). Facial stimulus evoked the most asymmetrical movement, whereas the masseteric produced the most symmetrical expression. The method can be used for assessing facial movements after facial reanimation

A six sigma DMAIC methodology as a support tool for health technology assessment of two antibiotics

Health Technology Assessment (HTA) and Six Sigma (SS) have largely proved their reliability in the healthcare context. The former focuses on the assessment of health technologies to be introduced in a healthcare system. The latter deals with the improvement of the quality of services, reducing errors and variability in the healthcare processes. Both the approaches demand a detailed analysis, evidence-based decisions, and efficient control plans. In this paper, the SS is applied as a support tool for HTA of two antibiotics with the final aim of assessing their clinical and organizational impact in terms of postoperative Length Of Stay (LOS) for patients undergoing tongue cancer surgery. More specifically, the SS has been implemented through its main tool, namely the DMAIC (Define, Measure, Analyse, Improve, Control) cycle. Moreover, within the DMAIC cycle, a modelling approach based on a multiple linear regression analysis technique is introduced, in the Control phase, to add complementary information and confirm the results obtained by the statistical analysis performed within the other phases of the SS DMAIC. The obtained results show that the proposed methodology is effective to determine the clinical and organizational impact of each of the examined antibiotics, when LOS is taken as a measure of performance, and guide the decision-making process. Furthermore, our study provides a systematic procedure which, properly combining different and well-assessed tools available in the literature, demonstrated to be a useful guidance for choosing the right treatment based on the available data in the specific circumstance

BDUOL: Double Updating Online Learning on a Fixed Budget

Ministry of Education, Singapore under its Academic Research Funding Tier 1; Microsoft Research gran

electronic properties of the n type pdi8 cn2 organic semiconductor at the interface with sio2 addressing the role of adsorbed water molecules by means of optical second harmonic generation

We investigate the interfacial electronic properties of N,N'-bis(n-octyl)-(1,7&1,6)-dicyanoperylene-3,4:9,10-bisdicarboximide (PDI8-CN2) organic semiconductor films grown on silicon dioxide (SiO2) by polarization-resolved second harmonic generation optical spectroscopy. The analysis shows a non-uniform distribution of charge carriers in PDI8-CN2, whose spatial profile is affected by hydrophobic passivation of SiO2 surfaces by hexamethyldisilazane. An interpretation model strengthened by photoluminescence analysis is developed, based on the presence of the net charge localized at the SiO2 surface and on consequent charge redistribution in the organic semiconductor. Considerations are expounded suggesting a common and 'universal' mechanism for the bias stress effect in p-channel and n-channel organic field-effect transistors, related to proton migration toward SiO2 gate dielectrics

Identification of a 2-propanol analogue modulating the non-enzymatic function of indoleamine 2,3-dioxygenase 1

Abstract Indoleamine 2,3 dioxygenase 1 (IDO1) is a metabolic enzyme that catalyzes the conversion of the essential amino acid tryptophan (Trp) into a series of immunoactive catabolites, collectively known as kynurenines. Through the depletion of Trp and the generation of kynurenines, IDO1 represents a key regulator of the immune responses involved in physiologic homeostasis as well as in neoplastic and autoimmune pathologies. The IDO1 enzyme has been described as an important immune checkpoint to be targeted by catalytic inhibitors in the treatment of cancer. In contrast, a defective expression/activity of the enzyme has been demonstrated in autoimmune diseases. Beside its catalytic activity, the IDO1 protein is endowed with an additional function associated with the presence of two immunoreceptor tyrosine-based inhibitory motifs (ITIMs), which, once phosphorylated, bind SHP phosphatases and mediate a long-term immunoregulatory activity of IDO1. Herein, we report the screening of a focused library of molecules bearing a propanol core by a protocol combining microscale thermophoresis (MST) analysis and a cellular assay. As a result, the combined screening identified a 2-propanolol analogue, VIS351, as the first potent activator of the ITIM-mediated function of the IDO1 enzyme. VIS351 displayed a good dissociation constant (Kd = 1.90 μM) for IDO1 and a moderate cellular inhibitor activity (IC50 = 11.463 μM), although it did not show any catalytic inhibition of the recombinant IDO1 enzyme. Because we previously demonstrated that the enzymatic and non-enzymatic (i.e., ITIM-mediated) functions of IDO1 reside in different conformations of the protein, we hypothesized that in the cellular system VIS351 may shift the dynamic conformational balance towards the ITIM-favoring folding of IDO1, resulting in the activation of the signaling rather than catalytic activity of IDO1. We demonstrated that VIS351 activated the ITIM-mediated signaling of IDO1 also in mouse plasmacytoid dendritic cells, conferring those cells an immunosuppressive phenotype detectable in vivo. Thus the manuscript describes for the first time a small molecule as a positive modulator of IDO1 signaling function, paving the basis for an innovative approach to develop first-in-class drugs acting on the IDO1 target